Congratulations to Jenna Beyer and Adam Green who both won prizes for their poster presentations at the recent departmental retreat!
George and Nicole both spoke at the Penn Epigenetics Institute Retreat at the Phillies Stadium and Nicole came home with a poster prize! Congratulations Nicole!
The Burslem Lab ran the 5K for the Penn Institute on Aging on Sunday Morning - Well done everyone!
We’re pleased to welcome two new lab members!
Brianna Hill-Payne joins us as a Rotation Student from the Biochemistry and Molecular Biophysics Graduate Group having previously spend time in various academic and industrial labs!
Trenton Winters joins us as a research specialist following his BS in Biochemistry from University of Notre Dame and will be working on peptide-protein interactions and keeping us all organized!
Welcome to the lab!
In this paper in RSC Medicinal Chemistry we used a catalyst free photochemical transformation to explore new chemical space for epigenetic drug discovery!
Read more here
The lab was recently awarded an R35 Maximizing Investigators' Research Award (MIRA) Grant from the NIH to support our work over the next 5 years!
The lab was recently awarded a grant from the Leukemia Research Foundation to support our work!
More details here
Check out Adam and Georges J.Med.Chem perspective on epigenetic compound libraries Here
We’re pleased to welcome two new lab members!
Gabrielle Blizard joins us as BMB rotation student following her MS in Biology and BS in Biochemistry and Cell Biology from UCSD.
Maxxum Fioriti also joins us as a BMB rotation student, coming from the University of Rochester with a BS in Molcular Genetics.
Welcome to the lab!
https://www.aacr.org/meeting/aacr-annual-meeting-2021/nextgen-stars/
George’s review on the role chemical biology in combating the current pandemic is online now!
The role of chemical biology in the fight against SARS-CoV-2
We’re pleased to welcome two new lab members!
Adam Green joins us as a Postdoctoral Researcher following his PhD with Prof. Adam Nelson at the University of Leeds in the UK. Adams expertise is in synthetic chemistry and he will be synthesizing novel chemical biology probes in the lab.
Karine Kasti joins us as a research specialist following her BA in Chemistry from Emory University. Karine is the labs cell biology expert and also keeps us all organized!
Welcome to the lab!
After an extended virtual rotation and short shift-based lab rotations both Jenna Beyer and Nicole Raniszewski have decided to join the lab for their thesis projects!
Welcome to the lab!
We employed a scaffold hopping approach to enhance the activity of a previously reported BCR-Abl PROTAC. This represents a significant advance in the PROTAC field since it abrogates the need to optimize the linker to access a more potent degrader. The new PROTAC demonstrates a >10 fold increase in ability to induce degradation and possesses in vivo activity.
Check it out here!
Burslem and Crews provide a guide to the design, implementation, and therapeutic and basic research applications of PROTACs, small molecules designed to induce protein degradation.
Welcome to our website!