Publications
42. Sortase mediated ubiquitination with defined chain length and topology, N.R. Raniszewski, J.N. Beyer, M.I. Noel, G.M. Burslem, RSC Chemical Biology, 2024, DOI: 10.1039/D3CB00229B
41. Lead-Oriented Synthesis of Epigenetic Relevant Scaffolds, T. Maujean, P. Kannaboina, A.I. Green and G.M. Burslem, Chemical Communications, 2023, DOI: 10.1039/D3CC04317G
40. Regulation of eDHFR-tagged proteins with trimethoprim PROTACs, J.M. Etersque, I.K. Lee, N. Sharma, K.Xu, A. Ruff, J.D. Northrup, S.Sarkar, T Nguyen, R. Lauman, G.M. Burslem and M.A. Sellmyer, Nature Communications, 2023, DOI: 10.1038/s41467-023-42820-3
39. Direct Measurements of FLASH-Induced Changes in Intracellular Oxygenation, M. El Khatib, A.O. Motlagh, J. Beyer, S.R. Allu, Q. Sun, M.M. Kim, T.Troxler, E.E. Diffenderfer, G.M. Burslem, S.A. Vinogradov, International Journal of Radiation Oncology - Biology - Physics, 2023, DOI:10.1016/j.ijrobp.2023.09.019
38. A Chicken Tapasin ortholog can chaperone empty HLA-B*37:01 molecules independent of other peptide-loading components, G.F. Papadaki, C. H. Woodward, M.C. Young, T. J. Winters, G.M. Burslem, and N.G. Sgourakis –Journal of Biological Chemistry, 2023, DOI: 10.1016/j.jbc.2023.105136
37. Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes. Y. Sun, M.C. Young, C. H. Woodward, J.N. Danon, S. Gupta, H. Truong, T. J. Winters, G.M. Burslem, and N.G. Sgourakis, PNAS, 2023, DOI:10.1073/pnas.2304055120
36. RAB27B Controls Palmitoylation Dependent NRAS Trafficking and Signaling in Leukemia, J. Ren, B.Xing, R.A. O’Keefe, K. Lv, R.Wang, K.M. Bauer, A.Ghazaryan, G.M. Burslem, J. Zhang, R.M. O’Connell, V. Pillai, E.O. Hexner, Mark R. Philips, and W.Tong, Journal of Clinical Investigation, 2023, DOI: 10.1172/JCI165510
35. Chemical Probe Mediated Visualization of Protein S-palmitoylation in Patient Tissue Samples, N.Schek, J-Y. Lee, G.M. Burslem and E.S. Witze – Frontiers in Physiology, 2023, doi.org/10.3389/fphys.2023.1063247
34. Xeno-interactions between MHC-I Proteins and Molecular Chaperones Enable Peptide Exchange on Disease-relevant HLA Allotypes, Y. Sun, G.F. Papadaki, C.A. Devlin, J. Danon, M. Young, T.J. Winters, G.M. Burslem, E. Procko, and N. G. Sgourakis – Science Advances, 2023, DOI: 10.1126/sciadv.ade7151
33. The Importance of Controls in Targeted Protein Degradation: Determining Mechanism, B. Hill-Payne, S. Dilones and G.M. Burslem, Methods in Enzymology, 2022, doi.org/10.1016/bs.mie.2022.10.006
32. TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules, A.C. McShan, C.A. Devlin, G. F. Papadaki, Y.Sun, A.I. Green, G.I. Morozov, G.M. Burslem, E. Procko and N.G. Sgourakis, Nature Chemical Biology, 2022, DOI: 10.1038/s41589-022-01049-9
31. The Chemical Biology of Ubiquitin, G.M. Burslem, Biochimica et Biophysica Acta, 2021, DOI:10.1016/j.bbagen.2021.130079 - Rising Stars Special Issue
30. The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation, M. Grasso, G.J. Bond, Y. Kim, S. Boyd, M. Matson Dzebo, S. Valenzuela, T. Tsang, N.A. Schibrowsky, K.B. Alwan, N.J. Blackburn, G.M. Burslem, P. Wittung-Stafshede, D.D. Winkler, R. Marmorstein and D.C. Brady, Journal of Biological Chemistry, 2021, DOI:10.1016/j.jbc.2021.101314
29. Photochemical Synthesis of an Epigenetic Focused Tetrahydroquinoline Library, A.I. Green and G.M. Burslem, RSC Medicinal Chemistry, 2021, 10.1039/D1MD00193K
28. Focused Libraries for Epigenetic Drug Discovery: The Importance of Isosteres, A.I. Green and G.M. Burslem, J. Med. Chem, 2021, 10.1021/acs.jmedchem.1c00592
27. The Role of Chemical Biology in the Fight against SARS-CoV-2, G.M. Burslem, Biochem J, 2021, 478, 157–177.
26. Advances and Opportunities in Epigenetic Chemical Biology, J. Beyer, N. Raniszewski and G.M. Burslem, ChemBioChem, 2020, DOI: 10.1002/cbic.202000459
25. Scaffold hopping enables direct access to more potent PROTACs with in vivo activity, G.M. Burslem, D.P. Bondeson and C.M. Crews, Chemical Communications, 2020, DOI: 10.1039/D0CC02201B
24. Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery, G.M. Burslem and C.M. Crews, 2020, Cell, DOI: 10.1016/j.cell.2019.11.031
23. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation, G.M. Burslem, A. Reister-Schultz, D.P. Bondeson, C. Eide, S. Savage, B. Druker and C.M. Crews, Cancer Research, 2019, DOI: 10.1158/0008-5472.CAN-19-1236
22. Protein Folding State-Dependent Sorting at the Golgi Apparatus, D. Hellerschmied, Y.V. Serebrenik, L. Shao, G.M. Burslem and C.M. Crews, Molecular Biology of the Cell, 2019, DOI:10.1091/mbc.E19-01-0069
21. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion, G.M. Burslem, J. Song, X. Chen, J. Hines and C.M. Crews, J. Am. Chem. Soc., 2018, 140, 16428
20. Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure Degradation Relationships. G.M. Burslem*, P. Ottis, S. Jaime-Figueroa, A. Morgan, P.M. Cromm, M. Toure and C.M. Crews*, ChemMedChem, 2018, 12, 1508 *Co-corresponding authors
19. Lessons on Selective Degradation with a Promiscuous Warhead: Informing PROTAC Design, D.P. Bondeson, B.E. Smith, G.M. Burslem, A.D. Buhimschi, J. Hines, S. Jaime-Figueroa, J. Wang, B. Hamman, A. Ishchenko, C.M. Crews, Cell Chemical Biology, 2018, 25, 78
18. The Advantages of Targeted Protein Degradation over Inhibition: a RTK Case Study, G.M. Burslem, B.E. Smith, A. Lai, S. Jaime-Figueroa, D. McQuaid, D.P. Bondeson, M. Toure, H. Dong, Y. Qian, J. Wang, A.P. Crew, J. Hines and C. M. Crews, Cell Chemical Biology, 2018, 25, 67
17. Small Molecule Modulation of Protein Homeostasis, G.M. Burslem and C.M. Crews, Chemical Reviews, 2017, 117, 11269
16. Double Quick, Double “Click” Reversible Peptide “Stapling”, C.M. Grison, G.M. Burslem, J.A. Miles, L. Pilsl, D.J. Yeo, S.L. Warriner, M. E. Webb and A. J. Wilson, Chemical Science, 2017, 8, 5166
15. Hypoxia Inducible Factor as a Model for Studying Inhibition of Protein-Protein Interactions, G.M. Burslem, H.F. Kyle, A.S. Nelson, T.A. Edwards, A.J. Wilson, Chemical Science, 2017, 8, 4188
14. Expeditious Synthesis of Isoquinolones and Isocoumarins with a Vinyl Borane as an Acetylene Equivalent, M. Toure, S. Jaime-Figueroa, G.M. Burslem, C.M. Crews, Eur. J. Org. Chem., 2016, 24, 4171
13. Towards "Bionic" Proteins: Replacement of Continuous Sequences from HIF-1α with Proteomimetics to Create Functional p300 Binding HIF-1α Mimics, G.M. Burslem, H.F. Kyle, A. L. Breeze, T.A. Edwards, S.L. Warriner, A. S. Nelson and A.J. Wilson, Chem. Commun., 2016, 52, 5421
12. Synthesis of Highly Functionalized Oligobenzamide Proteomimetic Foldamers by Late Stage Introduction of Sensitive Groups, G.M. Burslem, H.F. Kyle, P. Prabhakaran, A. L. Breeze, T.A. Edwards, S.L. Warriner, A. Nelson and A.J. Wilson, Org. Biomol. Chem. 2016, 14, 3782
11. Trivalent Gd-DOTA reagents for modification of biomolecules, M.J. Fisher, D.J. Williamson, G.M. Burslem, J.P. Plante, I.W. Manfield, C. Tiede, J.R. Ault, P.G. Stockley, S. Plein, A. Maqbool, D.C. Tomlinson, R. Foster, S.L. Warriner and R.S. Bon, RSC Adv., 2015, 5, 96194
10. Exploration of the HIF-1α/p300 binding interface using peptide and adhiron phage display technologies to locate binding hot-spots for inhibitor development, H. F. Kyle, K. F. Wickson, J. Stott, G. M. Burslem, A. L. Breeze, D. C. Tomlinson, S. L. Warriner, A. Nelson, A. J. Wilson and T. A. Edwards, Mol. Biosyst., 2015, 11, 2738
9. Development of Solvent-Free Synthesis of Hydrogen-Bonded Supramolecular Polyurethanes, K.A. Houton, G.M. Burslem and A.J. Wilson, Chemical Science, 2015, 6, 2382
8. Aminomethyl hydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries, I. Colomer, O. Adeniji, G.M. Burslem, P. Craven, M.O. Rasmussen, A. Willaume, T. Kalliokoski, R. Foster, S. Marsden and A. Nelson, Bioorganic and Medicinal Chemistry, 2015, 23, 2736
7. Multivalent helix mimetics for PPI-Inhibition, A. Barnard, J. Miles, G.M. Burslem, A.M. Barker and A.J. Wilson, Org. Biomol. Chem., 2015, 13, 258
6. Orthogonal functionalization of α-helix mimetics, A. Barnard, K. Long, D.J. Yeo, J. Miles, V. Azzarito, G.M. Burslem, P. Prabhakaran, T.A. Edwards and A.J. Wilson, Org. Biomol. Chem., 2014, 12, 6794
5. Small molecule proteomimetic inhibitors of the HIF-1α/p300 protein-protein interaction, G.M. Burslem, H. Kyle, A. Breeze, T.A. Edwards, A. Nelson, S.L. Warriner and A.J. Wilson, ChemBioChem, 2014, 15, 1083
4. A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds, T. James, P. MacLellan, G.M. Burslem, I. Simpson, A. Grant, S.L. Warriner, V. Sridharan and A. Nelson, Org. Biomol. Chem., 2014, 12, 2584
3. Synthesis of oligobenzamide α-helix mimetics, G.M. Burslem and A.J. Wilson, Synlett, 2014, 25, 324
2. Click-enabled heterotrifunctional template for sequential bioconjugation, D.M. Beal, V.E. Albrow, G.M. Burslem, L. Hitchen, C. Fernandes, C. Lapthorn, L.R. Roberts, M.D. Selby and L.H. Jones., Org. Biomol. Chem., 2012, 10, 548
1. In-cell click labelling of small molecules to determine subcellular localisation, L.H. Jones, D. Beal, M.D. Selby, O. Everson, G.M. Burslem, P. Dodd, J. Millbank, T. Tran, F. Wakenhut, E.J.S. Graham and P. Targett-Adams, J. Chem. Biol., 2011, 4, 49